Xanthine Oxidase during Human Fetal Development

Detection of xanthine oxidase in human plasma.

Xanthine oxidase is a highly versatile enzyme which is widely distributed among various species. Though the presence of the enzyme in serum is not yet established, high antibody titre of this enzyme has been reported. Xanthine oxidase is thought to be the principal source of free radical generation via degradation of nucleotides to the end product, uric acid. The aim of this study was to detect...

Xanthine oxidase: introductory remarks.

At the 661st Meeting of the Biochemical Society, held at Bath, the Host Colloquium, a joint meeting with the Society for Free Radical Research, took place on 10th and 11th April 1997. Its title was ‘Xanthine oxidase: enzymology and pathophysiology’. The two aspects of xanthine oxidase research specified in the Colloquium title have developed remarkably separately, and, for a number of reasons, ...

The Ovary during Human Fetal Development

Xanthine oxidase inhibitor allopurinol attenuates the development of diabetic cardiomyopathy

In this study, we investigated the effect of the xanthine oxidase (XO) inhibitor, allopurinol (ALP), on cardiac dysfunction, oxidative-nitrosative stress, apoptosis, poly(ADP-ribose) polymerase (PARP) activity and fibrosis associated with diabetic cardiomyopathy in mice. Diabetes was induced in C57/BL6 mice by injection of streptozotocin. Control and diabetic animals were treated with ALP or pl...

The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic

35 Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) 36 from purine nucleotides. Numerous recent studies have revealed the prevalence of 37 metabolic syndrome including non-alcoholic fatty liver disease (NAFLD) or 38 steatohepatitis (NASH) to be related to hyperuricemia. However, it remains unclear 39 whether elevated serum UA during the development of NAFLD or NAS...